T follicular helper cell subsets: a potential key player in autoimmunity

T follicular helper cell subsets: a potential key player in autoimmunity

Blog Article

Follicular helper T (Tfh) cells are one of CD4+ helper T subsets which promote B cell maturation, activation and antigen-specific Draught Excluder antibody production.Autoantibodies are hallmarks of autoimmune diseases, and crucial contributions of Tfh cells in development of these diseases are now evident.Deregulation of Tfh activities can contribute to a pathogenic autoantibody production and can play an important role in the promotion Solar Mounts of autoimmune diseases.These days multiple researchers reported three subpopulations which has distinct effector functions in Tfh cells: Tfh1, Tfh2 and Tfh17 cells.In this review, we summarize the observed alterations in whole Tfh cells and subset distribution during autoimmune diseases.